The UFC Octagon is heading back to the Big Apple. The promotion returns to the iconic Madison Square Garden for UFC 281 in New York City on Saturday, Nov. 12. The card is a continuation of the strong finish to the 2022 calendar the UFC has put together, with two championship bouts headlining the event and many top UFC stars spread across the card. UFC 281 LIVE UFC 281 LIVE In the main event, Israel Adesanya defends his middleweight championship against Alex Pereira. The fight is something of a grudge match after Pereira twice defeated Adesanya in kickboxing, including a brutal knockout win in a 2017 bout. Adesanya will be making the sixth defense of his title. Carla Esparza is set to defend the women's strawweight title in the co-main event. Esparza will defend the belt against former champion Weili Zhang. This is the second world title reign for Esparza after she won the belt with a May split decision over Rose Namajunas. Rounding out the five-fight main card is Dustin Poirier vs. Michael Chandler in a battle of elite lightweights, former lightweight champion Frankie Edgar taking on Chris Gutierrez in bantamweight action and Dan Hooker vs. Claudio Puelles at lightweight. Below is the complete fight card with the latest odds from Caesars Sportsbook. Stay tuned to this page for any new or updates surrounding the event. UFC 281 fight card Israel Adesanya (c) -170 vs. Alex Pereira +145, middleweight championship Carla Esparza (c) +280 vs. Weili Zhang -360, women's strawweight championship Dustin Poirier -175 vs. Michael Chandler +150, lightweight Chris Gutierrez -210 vs. Frankie Edgar +175, bantamweight Dan Hooker -165 vs. Claudio Puelles +140, lightweight Renato Moicano -125 vs. Brad Riddell +105, lightweight Dominick Reyes -230 vs. Ryan Spann +190, light heavyweight Erin Blanchfield -280 vs. Molly McCann +230, women's flyweight Andre Petroski -210 vs. Wellington Turman +175, middleweight Karolina Kowalkiewicz -115 vs. Silvana Gomez Juarez -105, women's strawweight Choi Seung-woo -160 vs. Michael Trizano +135, featherweight Matt Frevola -150 vs. Ottman Azaitar +125, lightweight Montel Jackson -210 vs. Julio Arce +175, bantamweight Carlos Ulberg -125 vs. Nicolae Negumereanu +105, light heavyweight UFC 281 info Date: Nov. 12 Location: Madison Square Garden -- New York City Start time: 10 p.m. ET (Main card) How to watch: ESPN+ PPV